Aggregation of red blood cells: From rouleaux to clot formation
نویسندگان
چکیده
منابع مشابه
Aggregation of Red Blood Cells: From Rouleaux to Clot Formation
Red blood cells are known to form aggregates in the form of rouleaux. This aggregation process is believed to be reversible, but there is still no full understanding on the binding mechanism. There are at least two competing models, based either on bridging or on depletion. We review recent experimental results on the single cell level and theoretical analyses of the depletion model and of the ...
متن کاملRouleaux formation.
A 69-year-old man had lethargy and lower-back pain for several months. His physical findings showed mild congestive heart failure and no focal neurologic signs. The CBC was normal except for thrombocytopenia. Renal and hepatic function were normal. A sedimentation rate was markedly elevated, and his peripheral smear ( 40) is shown. The stacking of cells (rouleaux formation) facilitates the rate...
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BACKGROUND Hemorrhage and coagulopathy are major contributors to death after trauma. The contribution of red blood cells (RBCs) in correcting coagulopathy is poorly understood. Current methods of measuring coagulopathy may fail to accurately characterize in vivo clotting. We aimed to determine the effect of RBCs on clotting parameters by comparing resuscitation regimens containing RBCs and plas...
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The influence of red blood cell (RBC) aggregation on blood flow in vivo has been under debate since early 1900's, yet a full understanding has still has not been reached. Enhanced RBC aggregation is well known to increase blood viscosity measured in rotational viscometers. However, it has been demonstrated that RBC aggregation may decrease flow resistance in cylindrical tubes, due to the format...
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Recently experiments have been conducted to investigate the behavior of live human red blood cells under optical forces generated using both linearly and circularly polarized light [1, 2]. These experiments have shown that a normal human RBC, which has a biconcave disk shape, approximately 8 μm in diameter, deforms into a folded shape upon being placed in an optical trap; the trapped RBC subseq...
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ژورنال
عنوان ژورنال: Comptes Rendus Physique
سال: 2013
ISSN: 1631-0705
DOI: 10.1016/j.crhy.2013.04.004